![]() Subject to the implanted tissue “taking” in the host and achieving reasonable growth rates, the tumor tissue is subsequently passaged into further animals (P1, Pn, etc.) and becomes a PDX model. PDX, on the other hand, are generated by taking patient tumor tissue and directly implanting into a mouse, never growing in vitro. These cell lines have been adapted to grow on plastic, used for many generations, and are often greatly altered from original disease. In oncology, these have traditionally been cell line xenograft (CDX) models using tumor cells immortalized in vitro from patient tissues. In drug discovery, animal models are used to understand the efficacy, PD, PK, metabolism, and tolerability of candidate drugs. What are PDX and How are they Different from Cell Line Derived Xenografts?
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